Endocrine Abstracts

AimGlucagon stimulation test (GST) is used to assess hypothalamo-pituitary-adrenal (HPA) and GH axis with an incompletely defined mechanism. Glucagon has physiological effects on body weight and metabolic parameters and some of these effects are suggested to occur via fibroblast growth factor-21 (FGF-21) which is a circulating hepatokine. FGF-21 was also shown to affect HPA and GH axis in rodents. The aim of the present study was assess if glucagon acted...

Background: Cushing’s syndrome is a well-known risk factor for endothelial dysfunction, cardiovascular morbidity and mortality.Objectives: We aimed to prospectively investigate changes in metabolic and cardiovascular parameters and their correlations with markers of endothelial function in patients with endogenous Cushing syndrome following remission. Methods: Adult patients newly diagnosed with endogenous Cushing’s Syndr...

Backgound: Familial hypertriglyceridemia may lead to acute pancreatitis also during pregnancy in some cases. We present two cases with hypertriglyceridemia-induced pancreatitis that recurred despite diet and medical therapy during pregnancy.Case presentation: Twenty-eight-year-old woman presented with hypertriglyceridemia-induced pancreatitis (serum triglyceride: 8502 mg/dL) that was complicated with respiratory distress at 25 weeks of gestation. Followi...

Objective: Data on gender comparisons of diagnosis, management and prognostic factors in Cushing’s disease are very limited, however, there is no such a comparison in ectopic ACTH syndrome (EAS) in the literature. The aim of this study is to compare clinical and hormonal data, neuroendocrine tumor (NET) localization, treatment and survival outcomes in Cushing’s syndrome due to EAS by gender.Material-Methods: Eleven experienced centers from our ...

Background: Hypophysitis is a rare group of disease characterized with infla mmation of the pituitary gland. Rarity of the disease obviates development of a treatment strategy. We aimed to present the nationwide data of the demographics, clinical and radiological characteristics, treatment modalities and responses of the patients diagnosed with hypophysitis in a retrospective manner.Methods: The endocrinology clinics all over the country were invited to ...